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Beilstein J. Org. Chem. 2014, 10, 1741–1748, doi:10.3762/bjoc.10.181
Graphical Abstract
Scheme 1: Convergent construction of self-adjuvanting vaccines bearing multiple copies of a B cell epitope.
Scheme 2: Synthesis of carbohydrate building block 1.
Scheme 3: (A) Lipidation of Fmoc-Lys-OH with lauroyl chloride: (B) Lipidation of Fmoc-Lys-OH with sulfonic-ca...
Scheme 4: Convergent synthesis of self-adjuvanting vaccine candidate 10 consisting of lipidic adjuvanting moi...
Figure 1: Analytical HPLCs of copper-catalyzed alkyne–azide cycloaddition reaction at the start (top) and aft...
Scheme 5: Convergent synthesis of self-adjuvanting vaccine candidate 12 consisting of lipidic adjuvanting moi...